منابع مشابه
Obesity and hepatotoxins as risk factors for fatty liver disease.
Generally fatty liver disease (FLD) is attributed either to alcohol, diabetes mellitus, or obesity. To evaluate this commonly held clinical belief, a case-control study of FLD in Western Pennsylvania was conducted with 19 cases being identified over a two year period. Cases of FLD were significantly heavier and were significantly more likely than controls to have exposures to either agents with...
متن کاملThe Natural Degradation of Microcystins (Cyanobacterial Hepatotoxins) in Fresh Water – the Future of Modern Treatment Systems and Water Quality Improvement
The increasing occurrence of hepatotoxic cyanobacterial blooms in fresh waters is one of the most serious risks to human health in the 21 century. Therefore, proper management of waters contaminated with cyanobacteria requires elaboration of the appropriate methods to remove cyanobacterial hepatotoxins-microcystins (MCs) from the environment. Many chemical and physical procedures have been prop...
متن کاملResistance to hepatotoxins acquired by hepatocytes during liver regeneration.
The appearance of resistance to a number of hepatotoxins in primary cultures of hepatocytes prepared at various time intervals up to 2 weeks after partial hepatectomy is the major focus in this study. Resistance to the cytocidal effect of aflatoxin B1, 2-acetylaminofluorene, N-hydroxy-2-acetylaminofluorene, methotrexate, or methyl methanesulfonate shows a progressive increase until 48 hr and th...
متن کاملResistance to Hepatotoxins Acquired by Hepatocytes during Liver Regeneration1
The appearance of resistance to a number of hepatotoxins ¡nprimary cultures of hepatocytes prepared at various time intervals up to 2 weeks after partial hepatectomy is the major focus in this study. Resistance to the cytocidal effect of aflatoxin Bi, 2-acetylaminofluorene, N-hydroxy-2-acetylaminofluorene, methotrexate, or methyl methanesulfonate shows a pro gressive increase until 48 hr and t...
متن کاملCharacterization of the nodularin synthetase gene cluster and proposed theory of the evolution of cyanobacterial hepatotoxins.
Nodularia spumigena is a bloom-forming cyanobacterium which produces the hepatotoxin nodularin. The complete gene cluster encoding the enzymatic machinery required for the biosynthesis of nodularin in N. spumigena strain NSOR10 was sequenced and characterized. The 48-kb gene cluster consists of nine open reading frames (ORFs), ndaA to ndaI, which are transcribed from a bidirectional regulatory ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1965
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5457.361